RALEIGH, N.C. -- North Carolina State honored Kay Yow on Sunday -- first by wearing pink, then by duplicating one of the late coach's last big upsets.
The Wolfpack knocked off No. 10 Duke 72-59 behind 23 points from Miah Spencer.
Dominique Wilson added 18 points and hit four of the Wolfpack's 12 3-pointers, and Jennifer Mathurin finished with 13 points and 12 rebounds.
"I know Coach Yow would be proud of these kids," coach Wes Moore said. "We had the perfect storm."
N.C. State (16-11, 7-7 Atlantic Coast Conference) won its fourth in five games overall and earned its first regular-season victory over Duke since 2001.
The Wolfpack did earn memorable wins over the Blue Devils in two ACC tournaments, including a 2007 semifinal when Duke was unbeaten and ranked No. 1 and Yow returned from some time away to fight breast cancer.
This marked N.C. State's annual "Hoops 4 Hope" game in which the teams wear pink-trimmed uniforms for breast-cancer awareness and raise funds for the cancer fund that bears Yow's name.
"Playing where coach Kay Yow coached ... I've never won a game here in pink," Len'Nique Brown said. "My first time beating Duke. It means a lot."
Elizabeth Williams scored 19 points, Rebecca Greenwell added 16 and Azurá Stevens had 13 points and 10 rebounds for Duke (19-8, 10-4), which lost its second straight.
N.C. State scored 28 points off 18 turnovers by the Blue Devils, who gave it away on five straight possessions down the stretch after they pulled within four with less than 9 minutes left.
"Eighteeen of the worst turnovers I've ever seen," Duke coach Joanne P. McCallie said. "Terrible."
Stevens hit a free throw to bring Duke to 48-44 with 8:51 remaining. But after that, the Blue Devils simply couldn't keep control of the ball.
In the middle of Duke's giveaway spree, Brown hit a layup, Spencer buried a jumper and Jennifer Mathurin swished a 3 from the left corner to put N.C. State up 55-44 with 5 minutes left.
Duke never got closer than seven the rest of the way, and N.C. State iced it by hitting 13 of 14 free throws in the final 90 seconds.
Brown finished with 12 points for the Wolfpack, who shot 33 percent overall and 48 percent from 3-point range. Duke entered with the stingiest defense in the ACC, allowing teams to shoot just 34 percent overall and 28 percent from beyond the arc.
N.C. State took control of the game by hitting four 3s in a span of five possessions -- including two in a row by Wilson that made it 46-35 with 13 1/2 minutes left.
Williams had eight rebounds to give her 1,002 for her career, making her just the second player in Duke history with 1,000. The Blue Devils held a 50-33 advantage on the boards against a smaller N.C. State team of which Moore said "when we go through an airport right now, people think we're a miniature golf team."
Duke: Ka'lia Johnson's 3-pointer 30 seconds into the second half snapped a string of 18 missed 3s for the Blue Devils, a drought that began six nights earlier during a loss at No. 4 Notre Dame.
NC State: The Wolfpack end the season with three straight games against teams in the top 10. After visiting No. 9 Florida State on Thursday night, they wrap up against the Fighting Irish next Sunday.