The Blue Devils own an 80-6 record over the last six years in ACC regular season action.
Duke improved to 11-0 in road games this season.
Lindsey Harding dished out eight assists on the night, giving her 17 assists over the last two contests. She also added seven points and five rebounds.
Duke is coming off a seven-day break from games, after its 74-70 loss to third-ranked and now No. 1 ranked North Carolina.
The Blue Devils committed 20 turnovers for the second straight contest.
With her eight assists on the night, Lindsey Harding moved into sole possession of sixth place on the Duke all-time assist list with (391). She passed teammate Monique Currie (383).
Jessica Foley moved into third place on Duke's all-time three-pointers made list with her two treys on the night. She now owns 160 passing Jennifer Scanlon (159).
Chante Black reached double-figure points for the fifth time out of nine ACC contests as she finished with 10 points. She also added two rebounds and three blocks in 23 minutes.
Monique Currie registered her sixth 20-point game of the season and fourth against ACC opponents as she finished with 21 points.
Senior Mistie Williams tied a season high with 16 points for the second straight game, while adding seven rebounds, two blocks and two steals in only 25 minutes.
Duke's defense forced 24 turnovers on the night marking the 18th time out of 22 contests the Blue Devils have forced 20 or more turnovers.
The Blue Devils will return home for a two-game homestand which begins on Friday, Feb. 10 against Virginia at 7:00 p.m. Duke will then host sixth-ranked Maryland on Monday at 7:00 p.m. on ESPN2.